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The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking celecoxib. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. NSAIDs such as celecoxib may cause ulcers, bleeding, or holes in the stomach or intestine. If you will be undergoing a coronary artery bypass graft (CABG a type of heart surgery), you should not take celecoxib right before or right after the surgery. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Do not take an NSAID such as celecoxib if you have recently had a heart attack, unless directed to do so by your doctor.

This risk may be higher for people who take NSAIDs for a long time. These events may happen without warning and may cause death. People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as celecoxib may have a higher risk of having a heart attack or a stroke than people who do not take these medications.